Research
Metabolic adaptation
The long-acting PYY analogs improved glucose metabolism in diabetic db/db mice.
Indicates potential for improved glucose control in diabetic patients.
StrongSupportsmedium confidence
which improved glucose metabolism in diabetic db / db mice.
Why this rating
Based on the experimental results mentioned in the abstract.
Source
Variant screening of PYY <sub>3–36</sub> leads to potent long-acting PYY analogs with superior Y <sub>2</sub> receptor selectivity
Søren Østergaard et al. · Science Translational Medicine · 2025
DOI 10.1126/scitranslmed.adq6392
otherCited 8×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
More from this paper
- Variant screening of PYY 3–36 led to the development of highly selective long-acting analogs against the Y 2 receptor.Strong
- The combination of long-acting PYY analogs with a GLP-1 receptor agonist resulted in superior blood glucose lowering and greater body weight loss compared to GLP-1 alone.Strong
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