Research
Hormonal
Genetic variants (SNPs) associated with obesity have modest individual effects, but aggregated into genetic risk scores, they can interact with environmental factors (diet, activity) to amplify obesity risk.
Your genes play a role in your weight, but they are not the whole story. Environmental factors like diet and activity can amplify genetic risk. Managing these factors is crucial for those with a genetic predisposition to obesity.
ModerateSupportsMEDIUM confidence
Because of the modest effect of SNPs on obesity traits, researchers have aggregated multiple SNPs into genetic risk scores... factors that can amplify the association of genetic risk scores with BMI include increased consumption of sugar-containing beverages, increased fried food intake, decreased physical activity, sleep deprivation, and low socioeconomic status.
Why this rating
Review of genetic studies; heritability is high but explained variance by known SNPs is low.
Source
Precision Medicine for Obesity
Lizeth Cifuentes et al. · Digestive Disease Interventions · 2021
DOI 10.1055/s-0041-1729945
narrative_reviewCited 34×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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