Research
Hormonal
Semaglutide likely results in little to no difference in quality of life with a mean difference of 2.12 (95% CI 0.95 to 3.28) in SF-36 physical functioning score at medium-term follow-up.
While semaglutide aids in weight loss, its impact on quality of life may be minimal.
GoodQualifiesmedium confidence
Semaglutide likely results in little to no difference in quality of life (SF-36 physical functioning score: MD 2.12, 95% CI 0.95 to 3.28; 9 studies, 6083 participants; moderate-certainty evidence).
Why this rating
Based on moderate-certainty evidence from RCTs.
Source
Semaglutide for adults living with obesity
Javier Bracchiglione et al. · Cochrane Database of Systematic Reviews · 2025
DOI 10.1002/14651858.cd015092.pub2
Meta-analysisCited 7×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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