Research
Hormonal
The PA-GLP1 formulation resulted in an overall reduction in blood glucose levels and reduced weight gain compared to daily injections of semaglutide.
This formulation may be more effective than current daily treatments for diabetes.
StrongSupportsmedium confidence
Achieved sustained serum concentrations for at least 40 days, with an overall reduction in blood glucose levels and reduced weight gain, comparing favorably to daily injections of semaglutide.
Why this rating
Based on direct comparison with an established treatment.
Source
Engineering Supramolecular Nanofiber Depots from a Glucagon-Like Peptide-1 Therapeutic
Weike Chen et al. · ACS Nano · 2024
DOI 10.1021/acsnano.4c10248
otherCited 6×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
More from this paper
- The supramolecular GLP-1 receptor agonist (PA-GLP1) formulation achieved sustained serum concentrations for at least 40 days in a rat model of type 2 diabetes.Strong
- The engineered GLP-1 receptor agonist depot offers a more convenient and long-lasting therapeutic option for managing diabetes and treating metabolic disorders.Strong
Related findings · Hormonal
- Initial treatment for type 2 diabetes should be a combination of metformin and either an SGLT-2 inhibitor or a GLP-1 receptor agonist to achieve cardiorenal protection, rather than monotherapy or older agents like sulfonylureas.Strong
- For patients with specific monogenic obesity syndromes (leptin deficiency, POMC/PCSK1/LEPR mutations), targeted pharmacotherapy (recombinant leptin or setmelanotide) is highly effective and should be prioritized, unlike in polygenic obesity.Strong
- Continued weekly administration of 2.4 mg subcutaneous semaglutide prevents weight regain and promotes further weight loss in adults with overweight or obesity, whereas switching to placebo results in significant weight regain.Strong
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