Hormonal
Women tend to lose more weight than men when treated with GLP-1 receptor agonists (semaglutide, liraglutide) for obesity, despite men often losing more weight with lifestyle interventions alone.
If you are a woman being treated with GLP-1 medications like Wegovy or Saxenda, you are statistically likely to lose more weight than a man on the same drug. This is due to how your body processes the medication. Do not compare your progress to male baselines or lifestyle-only results; your pharmacological response is typically superior.
Recent data about sex differences suggest that women tend to lose more weight than men after taking weight loss drugs for 1 year... women lost more weight than men with liraglutide 3 mg once daily.
Why this rating
Based on pooled analysis of multiple large RCTs (STEP-1, SCALE, SCOUT) with statistically significant p-values.
Source
Obesity management: sex-specific considerations
Tobias Kantowski et al. · Archives of Gynecology and Obstetrics · 2024
DOI 10.1007/s00404-023-07367-0
More from this paper
- Men tend to lose more absolute weight than women when undergoing non-pharmacological lifestyle interventions (diet and exercise), although the difference is small.Good
- Women experience a higher incidence of gastrointestinal adverse events (nausea, vomiting) from GLP-1 receptor agonists compared to men, even at similar drug exposure levels.Good
Related findings · Hormonal
- Initial treatment for type 2 diabetes should be a combination of metformin and either an SGLT-2 inhibitor or a GLP-1 receptor agonist to achieve cardiorenal protection, rather than monotherapy or older agents like sulfonylureas.Strong
- For patients with specific monogenic obesity syndromes (leptin deficiency, POMC/PCSK1/LEPR mutations), targeted pharmacotherapy (recombinant leptin or setmelanotide) is highly effective and should be prioritized, unlike in polygenic obesity.Strong
- Continued weekly administration of 2.4 mg subcutaneous semaglutide prevents weight regain and promotes further weight loss in adults with overweight or obesity, whereas switching to placebo results in significant weight regain.Strong
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