Research
Hormonal
Women experience a higher incidence of gastrointestinal adverse events (nausea, vomiting) from GLP-1 receptor agonists compared to men, even at similar drug exposure levels.
Women are more likely to experience nausea and vomiting from GLP-1 drugs than men. This is a known side effect. Use the recommended slow titration schedule to minimize these symptoms.
GoodSupportsHIGH confidence
Available evidence suggests that side effects occur at a higher rate in women, especially affecting gastrointestinal (GI) adverse events... semaglutide-associated gastrointestinal AEs seemed to predominantly affect females (57.68%).
Why this rating
Based on pharmacovigilance data and post-hoc analyses of RCTs.
Source
Obesity management: sex-specific considerations
Tobias Kantowski et al. · Archives of Gynecology and Obstetrics · 2024
DOI 10.1007/s00404-023-07367-0
narrative_reviewCited 32×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
More from this paper
- Women tend to lose more weight than men when treated with GLP-1 receptor agonists (semaglutide, liraglutide) for obesity, despite men often losing more weight with lifestyle interventions alone.Good
- Men tend to lose more absolute weight than women when undergoing non-pharmacological lifestyle interventions (diet and exercise), although the difference is small.Good
Related findings · Hormonal
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- Continued weekly administration of 2.4 mg subcutaneous semaglutide prevents weight regain and promotes further weight loss in adults with overweight or obesity, whereas switching to placebo results in significant weight regain.Strong
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