Mixed
In older adults, satellite cells that are physically incarcerated by thickened laminin in the extracellular matrix exhibit significantly reduced activation in response to resistance exercise compared to non-incarcerated satellite cells.
If you are older and feel your muscles aren't responding to exercise as well as they used to, it may be due to structural changes in the muscle tissue (thickening of the outer layer around muscle stem cells) that 'trap' them. The good news is that consistent resistance training over several months can reverse this trapping process, allowing your muscle stem cells to activate properly again and support muscle growth.
In non-incarcerated SC, the proportion of active MyoD+/Pax7+ SC were higher compared to incarcerated SC (p<0.05) following a single bout of exercise.
Why this rating
Controlled human study with clear histological measurements and statistical significance, though small sample size for specific subgroup analyses.
Source
Age‐related changes to the satellite cell niche are associated with reduced activation following exercise
Joshua P. Nederveen et al. · The FASEB Journal · 2020
DOI 10.1096/fj.201900787r
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