Research
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None of the four glucagon-like peptide-1 receptor agonist (GLP-1RA) or glucose-dependent insulinotropic polypeptide (GIP)/GLP-1RA therapies were cost-effective compared with lifestyle management.
Practitioners should consider lifestyle management as the most cost-effective option for treating obesity in this population.
StrongRefutesmedium confidence
The base-case results indicated that, under the WTP threshold, none of the four glucagon-like peptide-1 receptor agonist (GLP-1RA) or glucose-dependent insulinotropic polypeptide (GIP)/GLP-1RA therapies were cost-effective compared with lifestyle management.
Why this rating
Based on a comprehensive cost-effectiveness analysis using a Markov model.
Source
Cost‐effectiveness analysis of four glucagon‐like peptide‐1 or glucose‐dependent insulinotropic polypeptide/glucagon‐like peptide‐1 receptor agonists for the treatment of adult patients with overweight and obesity in China
Wu Fu et al. · Diabetes Obesity and Metabolism · 2025
DOI 10.1111/dom.16581
Meta-analysisCited 4×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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