Research
Energy balance
Weight loss in the GLP-1 RA group was directly associated with bone loss at the total hip (TH) and femoral neck (FN).
Weight management strategies may need to consider potential impacts on bone health.
StrongSupportsmedium confidence
In the GLP-1RA group, weight loss was directly associated with bone loss at the TH and FN (r=0.32 for TH, r=0.17 for FN, both p<0.01).
Why this rating
Based on a retrospective study design with statistical analysis.
Source
Skeletal effect of semaglutide and tirzepatide in patients with increased risk of fractures
Yi Liu et al. · The Journal of Clinical Endocrinology & Metabolism · 2026
DOI 10.1210/clinem/dgag052
cohort · n=510Cited 4×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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- Semaglutide (SEM) and tirzepatide (TIR) use was associated with greater annualized total hip (TH) bone loss in patients without diabetes mellitus (DM) compared to controls.Strong
- Total hip (TH) bone loss was comparable between GLP-1 RA users and controls among patients with diabetes mellitus (DM).Strong
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