Research
Hormonal
HEC-C052, with the lowest GCG agonism, is less effective for weight loss compared to semaglutide.
Semaglutide may be preferred over HEC-C052 for weight loss in certain populations.
StrongRefutesmedium confidence
The weight change of HEC-C052 with the lowest GCG agonism was inferior to that of selective GLP-1 receptor agonist (GLP-1RA) semaglutide in DIO model mice.
Why this rating
Based on comparative analysis in a controlled study.
Source
The effects of Fc fusion protein glucagon-like peptide-1 and glucagon dual receptor agonist with different receptor selectivity in vivo studies
Peng Jiang et al. · Biomedicine & Pharmacotherapy · 2024
otherCited 4×
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