Browse the evidence

The melanocortin system is regulated by long-term and short-term regulatory hormones and nutrients.

Understanding the regulation of the melanocortin system can aid in appetite management strategies.

Bioactive compounds affect appetite regulation through the central nervous system, peripheral hormones, and intestinal microbiota.

Practitioners should consider multiple pathways when addressing appetite regulation.

Understanding novel mutations in POMC and MC4R/MC3R may help identify strategies for the treatment and diagnosis of obesity, particularly childhood obesity.

This knowledge can guide interventions for childhood obesity.

Metabolically healthy individuals experienced lower event rates with increasing body mass index (BMI).

Emphasizing metabolic health may lead to better outcomes even in individuals with higher BMI.

Greater total testosterone levels were associated with better verbal fluency in men.

Practitioners may consider that higher testosterone levels could enhance verbal fluency in men with T2DM.

Psychotropic medications, especially antipsychotics, cause weight gain in individuals with severe mental illness (SMI).

Practitioners should be aware of the weight gain side effects of antipsychotic medications in SMI patients.

Metformin and topiramate are commonly prescribed for weight gain in individuals with SMI, but their weight loss potential is modest.

Practitioners should consider the limited effectiveness of metformin and topiramate for weight management in SMI patients.

Antidiabetic medications impact skeletal muscle lipid metabolism.

Practitioners should consider the effects of antidiabetic medications on lipid metabolism when treating patients.

Current research has focused more on muscle mass than on skeletal muscle lipid metabolism.

Researchers should shift focus to skeletal muscle lipid metabolism in future studies.

Compounds K2 and K5 decreased and maintained the body weight of diet-induced obese mice.

Compounds K2 and K5 may be potential candidates for drug development targeting obesity.

The study proposes an approach for treating overweight and obese patients by preventing or reducing CCK1 activation.

This approach may inform future obesity treatments focusing on CCK1 regulation.

There is a weak positive association between BMI and KIDMED index in the physically active population, which was not statistically significant.

Practitioners should be cautious in interpreting the relationship between BMI and nutritional status.

Peanut hulls are an underutilized food source for human consumption that can improve nutrient-density in common foods.

Incorporating peanut hulls into foods can enhance their nutritional value.

Valorizing peanut hulls can address food waste and improve food security.

Utilizing peanut hulls can contribute to reducing food waste and enhancing food security.

Recent advances in sustainable food processing technologies can safely incorporate peanut hulls into human food streams.

Innovative processing technologies can enable the use of peanut hulls in food products.

Only 6.2% of Canadians with stroke met both moderate-vigorous physical activity (MVPA) and muscle-strengthening activity (MSA) guidelines.

Clinicians should focus on increasing physical activity among stroke patients.

88.2% of Canadians with stroke engaged in MVPA less than 3 times per week.

Encouragement for more frequent MVPA is necessary for stroke patients.

76.7% of Canadians with stroke never engaged in muscle-strengthening activities (MSA).

There is a need to promote MSA among stroke patients.

The median risk ratio estimated by participants for the overweight-mortality association was 1.59, indicating a perceived 59% increased mortality risk.

Practitioners can use this risk ratio to inform discussions with patients about the health risks of being overweight.

Nearly all providers believe treating obesity improves quality of life (99%) and survival (95%) after lung transplantation.

Practitioners should recognize the strong belief among providers that obesity management is crucial for lung transplant recipients.

Only 41% of patients attempting weight loss are successful according to provider beliefs.

Practitioners should be aware of the low success rate in weight loss efforts among lung transplant recipients.

There is a gap between general obesity treatment guidelines and lung transplant practice.

Practitioners may need additional training and education to align their practices with obesity treatment guidelines.

Adipose tissue browning is linked to improved metabolic and cardiovascular health.

Promoting adipose tissue browning may enhance metabolic and cardiovascular health.

Interventions like ASK-1 knockout, nitrate, and melatonin have increased thermogenesis and improved metabolic outcomes.

Consider these interventions to enhance thermogenesis in metabolic health strategies.