Research
Molecular
The MC4R rs17782313 polymorphism has positive effects on dietary glycemic index (GI) and glycemic load (GL) (B = 1.577; P ≤ 0.01 for GI; B = 1.235; P ≤ 0.01 for GL).
Understanding the genetic basis of GI and GL can inform dietary recommendations for obesity management.
StrongSupportsmedium confidence
MC4R rs17782313 polymorphism had positive effects on GI ( B = 1.577; P ≤ 0.01) and GL ( B = 1.235; P ≤ 0.01).
Why this rating
Based on the cross-sectional study design with clear statistical significance.
Source
The Role of Dietary Glycemic Index and Glycemic Load in Mediating Genetic Susceptibility via MC4R s17782313 Genotypes to Affect Cardiometabolic Risk Factors among Apparently Healthy Obese Individuals
Mahdieh Khodarahmi et al. · BioMed Research International · 2022
DOI 10.1155/2022/3044545
cross-sectional · n=287Cited 4×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
More from this paper
Related findings · Molecular
- QRISK decreased markedly after weight loss from 18.9 ± 2.2% to 11.2 ± 1.6%, p < 0.0001.Strong
- Normalization of 10-year cardiovascular risk and heart age is possible after substantial dietary weight loss and remission of T2DM.Strong
- The Low-Fat Plus diet resulted in a greater reduction in total cholesterol compared to the Low-Fat diet, with changes of -0.46 mmol/L (-17.6 mg/dL) versus -0.24 mmol/L (-9.2 mg/dL) respectively (P = 0.01).Strong
This is one finding among thousands. Every one is graded and traced to its source, so you can see what the evidence actually supports. Browse the research →