Research
Molecular
Glycemic index (GI) and glycemic load (GL) mediate the relationship between the MC4R variant and LDL cholesterol (LDL-C) levels.
Dietary management focusing on GI and GL may help mitigate LDL-C levels in genetically susceptible individuals.
StrongSupportsmedium confidence
This variant was found to be indirectly and positively associated with LDL‐C ( B = 6.589; P = 0.042) through mediatory effects of GI and GL.
Why this rating
Based on the cross-sectional study design with clear statistical significance.
Source
The Role of Dietary Glycemic Index and Glycemic Load in Mediating Genetic Susceptibility via MC4R s17782313 Genotypes to Affect Cardiometabolic Risk Factors among Apparently Healthy Obese Individuals
Mahdieh Khodarahmi et al. · BioMed Research International · 2022
DOI 10.1155/2022/3044545
cross-sectional · n=287Cited 4×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
More from this paper
- The MC4R gene variant rs17782313 is directly associated with the risk of metabolic syndrome (MetS) in obese adults (B = 0.010; P = 0.023).Strong
- The MC4R rs17782313 polymorphism has positive effects on dietary glycemic index (GI) and glycemic load (GL) (B = 1.577; P ≤ 0.01 for GI; B = 1.235; P ≤ 0.01 for GL).Strong
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