Research
Molecular
Glycemic index (GI) and glycemic load (GL) mediate the relationship between the MC4R variant and LDL cholesterol (LDL-C) levels.
Dietary management focusing on GI and GL may help mitigate LDL-C levels in genetically susceptible individuals.
StrongSupportsmedium confidence
This variant was found to be indirectly and positively associated with LDL‐C ( B = 6.589; P = 0.042) through mediatory effects of GI and GL.
Why this rating
Based on the cross-sectional study design with clear statistical significance.
Source
The Role of Dietary Glycemic Index and Glycemic Load in Mediating Genetic Susceptibility via MC4R s17782313 Genotypes to Affect Cardiometabolic Risk Factors among Apparently Healthy Obese Individuals
Mahdieh Khodarahmi et al. · BioMed Research International · 2022
cross-sectional · n=287Cited 4×
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