Research
Metabolic adaptation
Two weeks of step reduction (SR) increased HOMA-IR from 2.8 ± 0.3 to 3.6 ± 0.6 (p<0.05) and decreased MATSUDA from 3.7 ± 0.5 to 3.0 ± 0.1 (p<0.05), with neither recovering at post-SR.
Practitioners should be aware that even short periods of inactivity can significantly impair insulin sensitivity in older adults.
StrongSupportsmedium confidence
HOMA‐IR increased from pre‐SR to SR (2.8 ± 0.3 to 3.6 ± 0.6, p<0.05) and MATSUDA decreased (3.7 ± 0.5 to 3.0 ± 0.1, p < 0.05), neither recovered at post‐SR.
Why this rating
The study design involved controlled monitoring of activity and physiological measures.
Source
Only Two Weeks of Physical Inactivity Induces Insulin Resistance and Impairs Glycemic Control in Older Adults
Chris McGlory et al. · The FASEB Journal · 2016
DOI 10.1096/fasebj.30.1_supplement.734.2
cohort · n=13Cited 3×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
More from this paper
- Indices of glycemic control were negatively impacted by two weeks of SR and did not fully recover after 14 days of returning to habitual step count.Strong
- Muscle function indices, including peak isometric maximal voluntary contraction and total distance walked, remained unaltered during the study.Strong
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