Research
Cellular
Muscle function indices, including peak isometric maximal voluntary contraction and total distance walked, remained unaltered during the study.
Practitioners can note that short-term inactivity may not affect muscle function in older adults as significantly as metabolic health.
StrongSupportsmedium confidence
There was no change from pre‐SR to SR in either ISO‐MVC peak (146 ± 34 to 148 ± 41 N.m, p>0.05) or total distance walked in 6 min (561 ± 108 to 563 ± 110 m, p>0.05).
Why this rating
The study design involved controlled monitoring of activity and physiological measures.
Source
Only Two Weeks of Physical Inactivity Induces Insulin Resistance and Impairs Glycemic Control in Older Adults
Chris McGlory et al. · The FASEB Journal · 2016
DOI 10.1096/fasebj.30.1_supplement.734.2
cohort · n=13Cited 3×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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- Two weeks of step reduction (SR) increased HOMA-IR from 2.8 ± 0.3 to 3.6 ± 0.6 (p<0.05) and decreased MATSUDA from 3.7 ± 0.5 to 3.0 ± 0.1 (p<0.05), with neither recovering at post-SR.Strong
- Indices of glycemic control were negatively impacted by two weeks of SR and did not fully recover after 14 days of returning to habitual step count.Strong
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