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Initiation of semaglutide was significantly associated with a -3.8% reduction in weight at 13 to 24 months.
Semaglutide may be an effective option for weight management in adults.
StrongSupportsmedium confidence
In the overall cohort, initiation of semaglutide was significantly associated with a -3.8% (95% CI, -3.9% to -3.7%) reduction in weight at 13 to 24 months.
Why this rating
Based on a large retrospective cohort study.
Source
Changes in Cardiovascular Risk Factors and Health Care Expenditures Among Patients Prescribed Semaglutide
Yuan Lu et al. · JAMA Network Open · 2025
DOI 10.1001/jamanetworkopen.2025.26013
cohort · n=23522Cited 3×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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