Research
Energy balance
The appropriate use of NB-ER should consider the specific characteristics and adiposity-related complications of an individual.
Practitioners should assess individual patient characteristics when prescribing NB-ER.
StrongSupportsmedium confidence
The appropriate use of NB-ER should consider the specific characteristics and adiposity-related complications of an individual.
Why this rating
Based on the clinical review's recommendations.
Source
Appropriate use of the fixed-dose, extended-release combination of naltrexone and bupropion as treatment for obesity in primary care
Ethan Lazarus · Obesity Pillars · 2025
DOI 10.1016/j.obpill.2025.100170
reviewCited 3×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
More from this paper
- Patients can achieve significant weight reduction with the fixed-dose, extended-release combination of naltrexone and bupropion (NB-ER) compared with placebo when combined with a reduced-calorie diet and increased physical activity.Strong
- The unique combination of naltrexone and bupropion in NB-ER may work together to target POMC cells to prevent endogenous negative feedback, thereby decreasing appetite.Strong
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