Research
Neural
Patients can achieve significant weight reduction with the fixed-dose, extended-release combination of naltrexone and bupropion (NB-ER) compared with placebo when combined with a reduced-calorie diet and increased physical activity.
Practitioners should consider prescribing NB-ER for patients with obesity who are also engaging in dietary and physical activity changes.
StrongSupportsmedium confidence
Studies showing that patients can achieve significant weight reduction compared with placebo when treatment is combined with a reduced-calorie diet and increased physical activity.
Why this rating
Based on studies mentioned in the abstract.
Source
Appropriate use of the fixed-dose, extended-release combination of naltrexone and bupropion as treatment for obesity in primary care
Ethan Lazarus · Obesity Pillars · 2025
reviewCited 3×
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