Research
Metabolic adaptation
Metabolic adaptation hinders the efficacy of obesity management strategies.
Understanding metabolic adaptation can help practitioners develop more effective obesity management strategies.
StrongSupportsmedium confidence
A possible contributor is metabolic adaptation, a phenomenon characterized by reduced metabolic rate and energy expenditure following weight loss, which hinders therapeutic efficacy.
Why this rating
The claim is based on established concepts discussed in the abstract.
Source
Obesity and mitochondrial uncoupling – an opportunity for the carbon monoxide-based pharmacology of metabolic diseases
Aleksandra Danielak et al. · Pharmacological Research · 2025
reviewCited 3×
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