Research
Metabolic adaptation
Weight gain within the first 6 months was associated with increased risk of HbA1c >7.5% and subsequent cardiovascular disease (CVD) with a hazard ratio (HR) of 1.03.
Clinicians should monitor weight changes in T2D patients as it may impact glycemic control and cardiovascular health.
StrongSupportsmedium confidence
Weight gain within the first 6 months was associated with increased risk of HbA1c >7.5%, with modest differences by treatment, and with subsequent CVD (HR 1.03 [95% CI 1.005, 1.06]).
Why this rating
Based on a large randomized controlled trial.
Source
Weight Gain Was Associated With Worsening Glycemia and Cardiovascular and Kidney Outcomes in Patients With Type 2 Diabetes Independent of Diabetes Medication in the GRADE Randomized Controlled Trial
Deborah J. Wexler et al. · Diabetes Care · 2025
rct · n=4980Cited 3×
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