Research
Metabolic adaptation
Weight gain at 1 year was associated with increased risk of HbA1c >7.5% (HR 1.05) and kidney disease (HR 1.03).
Weight management is crucial for T2D patients to prevent worsening glycemic control and kidney disease.
StrongSupportsmedium confidence
Weight gain at 1 year was associated with increased risk of HbA1c >7.5% (HR 1.05 [1.04, 1.07]) and kidney disease (HR 1.03 [1.01, 1.06]).
Why this rating
Based on a large randomized controlled trial.
Source
Weight Gain Was Associated With Worsening Glycemia and Cardiovascular and Kidney Outcomes in Patients With Type 2 Diabetes Independent of Diabetes Medication in the GRADE Randomized Controlled Trial
Deborah J. Wexler et al. · Diabetes Care · 2025
rct · n=4980Cited 3×
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