Research
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High-dose canagliflozin (300 mg/day) is significantly associated with reduced sepsis risk versus control.
Practitioners may consider high-dose canagliflozin as a safer option regarding sepsis risk.
StrongSupportsmedium confidence
high-dose canagliflozin (300 mg/day), which was the only intervention significantly associated with reduced sepsis risk versus control.
Why this rating
Based on the analysis of 105 randomized controlled trials.
Source
The effect of GLP-1 receptor agonist and SGLT2 inhibitor on infection risk: network meta-analysis
Bing-Syuan Zeng et al. · Clinical Microbiology and Infection · 2026
DOI 10.1016/j.cmi.2026.01.014
Meta-analysisCited 2×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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