Research
Neural
GLP-1 receptor agonists can induce psychiatric side effects such as increased impulsivity, dysphoria, and aggression.
Physicians should be cautious of potential psychiatric side effects when prescribing GLP-1 RAs.
StrongSupportsmedium confidence
we present the case of a 64-year-old man who was started on the GLP-1 RA tirzepatide (Zepbound) and subsequently developed increased impulsivity, dysphoria, and aggression.
Why this rating
Based on the case report design.
Source
A Case of GLP-1 Receptor Agonist-Induced Dysphoria and Aggression in a Patient With Underlying Major Depressive Disorder
Mia Hofstad et al. · Journal of Psychiatric Practice · 2026
case_studyCited 2×
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