Research
Energy balance
GLP-1 receptor agonist treatment is associated with a 10.3% reduction in fat mass (FM) at 6 months, 17.3% at 12 months, and 18.0% at 24 months.
GLP-1RA treatment leads to significant fat mass reduction over 24 months.
StrongSupportsmedium confidence
Reductions in the GLP-1RA group were 10.3% (95% CI, 9.5%-11.0%) at 6 months, 17.3% (95% CI, 16.5%-18.1%) at 12 months, and 18.0% (95% CI, 16.4%-19.7%) at 24 months.
Why this rating
Based on a large cohort study design.
Source
Body Composition Changes After Bariatric Surgery or Treatment With GLP-1 Receptor Agonists
Zicheng Wang et al. · JAMA Network Open · 2026
cohort · n=3066Cited 2×
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