Research
Energy balance
The mean four-month weight loss percentage was statistically lower in the compounded Semaglutide group (9.11%) compared to the pure Semaglutide group (9.87%).
Practitioners should be aware that compounded Semaglutide may result in slightly less weight loss compared to pure Semaglutide.
StrongRefutesmedium confidence
The mean four-month weight loss percentage was statistically lower in the compounded Semaglutide group (N = 923, M = 9.11, SD = ±5.76) compared to those in the pure Semaglutide group (n = 1858, M = 9.87, SD = ±6.46), t (2032) = −3.15, p = 0.0017.
Why this rating
Based on the retrospective comparative study design with a large sample size.
Source
Effectiveness and Side Effect Incidence in a Real-World Digital Weight-Loss Service Using Compounded Semaglutide: A Retrospective Comparative Study
Louis Talay et al. · Obesities · 2024
DOI 10.3390/obesities4040032
cohort · n=2781Cited 2×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
More from this paper
- A statistically lower proportion of patients in the compounded Semaglutide group (71.61%) reported at least one side effect compared to the pure Semaglutide group (77.40%).Strong
- A significantly higher rate of patients from the pure Semaglutide group achieved the ten percent (50.54% vs. 44.64%) and fifteen percent (21.42% vs. 12.78%) weight loss thresholds compared to the compounded Semaglutide group.Strong
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