Research
Energy balance
A significantly higher rate of patients from the pure Semaglutide group achieved the ten percent (50.54% vs. 44.64%) and fifteen percent (21.42% vs. 12.78%) weight loss thresholds compared to the compounded Semaglutide group.
Practitioners should note that pure Semaglutide may lead to better outcomes in achieving significant weight loss thresholds.
StrongSupportsmedium confidence
A significantly higher rate of patients from the pure Semaglutide group achieved the ten (50.54% vs. 44.64%), X2 (1, N = 7683) = 10.34, p < 0.001, and fifteen (21.42% vs. 12.78%), X2 (1, N = 7683) = 30.43, p < 0.001, percent weight loss thresholds than patients from the compounded Semaglutide group.
Why this rating
Based on the retrospective comparative study design with a large sample size.
Source
Effectiveness and Side Effect Incidence in a Real-World Digital Weight-Loss Service Using Compounded Semaglutide: A Retrospective Comparative Study
Louis Talay et al. · Obesities · 2024
DOI 10.3390/obesities4040032
cohort · n=2781Cited 2×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
More from this paper
- The mean four-month weight loss percentage was statistically lower in the compounded Semaglutide group (9.11%) compared to the pure Semaglutide group (9.87%).Strong
- A statistically lower proportion of patients in the compounded Semaglutide group (71.61%) reported at least one side effect compared to the pure Semaglutide group (77.40%).Strong
Related findings · Energy balance
- Achieving a total body weight loss of 10-15% (or >10-15 kg) through Total Diet Replacement (TDR) induces remission of Type 2 Diabetes in individuals with short-duration disease.Strong
- Bariatric surgery is superior to medical management alone for inducing significant long-term weight loss, remission of type 2 diabetes, and reduction in mortality for patients with BMI ≥ 40 or ≥ 35 with comorbidities.Strong
- Achieving type 2 diabetes remission requires significant weight loss (≥15 kg) via major caloric restriction, independent of macronutrient composition.Strong
This is one finding among thousands. Every one is graded and traced to its source, so you can see what the evidence actually supports. Browse the research →