Research
Molecular
A maladaptive adipokine milieu is associated with endothelial dysfunction, myocardial stiffening, and muscle atrophy in HFpEF.
Recognizing this cycle can inform targeted interventions.
StrongSupportsmedium confidence
A maladaptive adipokine milieu associates with a self-reinforcing cycle of endothelial dysfunction, myocardial stiffening, and muscle atrophy that characterizes HFpEF in the context of obesity and sarcopenia.
Why this rating
The abstract summarizes a review of current evidence.
Source
The Adipokine Axis in Heart Failure: Linking Obesity, Sarcopenia and Cardiac Dysfunction in HFpEF
Luka Komić et al. · International Journal of Molecular Sciences · 2026
DOI 10.3390/ijms27020612
reviewCited 2×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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