Research
Metabolic adaptation
MRs cause a greater decrease in FBS, insulin, and HOMA-IR in individuals over 50 years old compared to those aged 50 years or younger.
Older adults may benefit more from meal replacements in terms of glucose metabolism.
StrongSupportsmedium confidence
The findings obtained from the subgroup analysis showed that MRs cause a greater decrease in FBS, insulin, and HOMA-IR in the >50-years age group compared with those aged ≤50 years.
Why this rating
Based on a meta-analysis of 52 studies.
Source
Effect of Total and Partial Meal Replacements on Factors Related to Glucose Metabolism: A Systematic Review and Meta-analysis of Randomized Controlled Trials
Niloofar Sadat Maddahi et al. · Nutrition Reviews · 2025
Meta-analysisCited 2×
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