Research
Energy balance
Weight decreases of 1.0% to 2.9%, 3.0% to 4.9%, and 5.0% or greater are associated with a lower risk of type 2 diabetes by 16%, 25%, and 26%, respectively.
Encouraging weight loss can significantly reduce the risk of developing type 2 diabetes.
StrongSupportsmedium confidence
Compared with participants with stable body weight (<1.0% change), those with weight decreases of 1.0% to 2.9%, 3.0% to 4.9%, and 5.0% or greater showed a lower risk of type 2 diabetes (16% [8%-24%; P < .001]; 25% [15%-34%; P < .001]; and 26% [14%-36%; P < .001], respectively).
Why this rating
Based on a large prospective cohort study.
Source
Effect of Weight Change on Type 2 Diabetes Risk: A Prospective Study in a Japanese Population
Takuya Kagisaki et al. · The Journal of Clinical Endocrinology & Metabolism · 2025
cohort · n=41539Cited 2×
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