Research
Energy balance
Weight increases of 1.0% to 2.9%, 3.0% to 4.9%, and 5.0% or greater are associated with a higher risk of type 2 diabetes by 15%, 35%, and 51%, respectively.
Weight gain should be avoided to reduce the risk of developing type 2 diabetes.
StrongSupportsmedium confidence
Conversely, those with weight increases of 1.0% to 2.9%, 3.0% to 4.9%, and 5.0% or greater showed a higher risk (15% [4%-26%; P = .005], 35% [20%-53%; P < .001], and 51% [29%-76%; P < .001], respectively).
Why this rating
Based on a large prospective cohort study.
Source
Effect of Weight Change on Type 2 Diabetes Risk: A Prospective Study in a Japanese Population
Takuya Kagisaki et al. · The Journal of Clinical Endocrinology & Metabolism · 2025
DOI 10.1210/clinem/dgaf558
cohort · n=41539Cited 2×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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