Mixed
A 3-month calorie-restricted ketogenic diet (KD) produces significantly greater weight loss than a calorie-restricted Mediterranean diet (MedDiet) in adults with obesity.
To lose more weight than a standard Mediterranean diet in 3 months, switch to a ketogenic diet with a 600-calorie daily deficit. This means eating very few carbs (5% of calories), moderate protein (30%), and high fat (65%). Ensure you are consuming enough calories to maintain basic function but below your maintenance level.
Significant differences in weight loss from baseline to 3 months were found between KD and the control group [− 3.78 kg (− 5.65 to − 1.91 kg)]... These results suggest that a calorie-restricted KD... may be more effective for weight loss than a calorie-restricted MedDiet in obesity.
Why this rating
Randomized clinical trial with 140 completers, but short duration (3 months) and lack of blinding.
Source
Effect of a ketogenic diet, time-restricted eating, or alternate-day fasting on weight loss in adults with obesity: a randomized clinical trial
José Ignacio Martínez‐Montoro et al. · BMC Medicine · 2025
DOI 10.1186/s12916-025-04182-z
More from this paper
- Modified Alternate-Day Fasting (mADF) produces significantly greater weight loss than a calorie-restricted Mediterranean diet (MedDiet) in adults with obesity.Good
- Late Time-Restricted Eating (lTRE) with an 8-hour window (2 pm - 10 pm) produces significantly greater weight loss than a calorie-restricted Mediterranean diet (MedDiet) in adults with obesity.Good
- Early Time-Restricted Eating (eTRE) with an 8-hour window (8 am - 4 pm) does NOT produce significantly greater weight loss than a calorie-restricted Mediterranean diet (MedDiet) in adults with obesity.Good
Related findings · Mixed
- Bariatric surgery (VSG and RYGB) is the most effective and sustainable treatment for obesity, producing marked and sustained weight loss that non-surgical interventions cannot match.Strong
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- For patients with Class III obesity (BMI >39.9 kg/m2), metabolic bariatric surgery (MBS) is significantly more effective than any currently approved medication, with BilioPancreatic Diversion (BPD) showing the highest estimated weight loss.Strong
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