Research
Molecular
The effects of rifampicin on obesity are mediated through Sirt6.
Targeting Sirt6 may enhance the effectiveness of rifampicin in obesity treatment.
StrongSupportsmedium confidence
Importantly, deletion of adipose Sirt6 abolishes the effects of rifampicin on HFD-induced weight gain and obesity in mice.
Why this rating
The conclusion is drawn from experimental evidence presented in the abstract.
Source
Rifampicin prevents diet-induced obesity through Sirt6-dependent lipolysis, adipocyte browning and lipogenesis inhibition
Yang Xu et al. · Biomedicine & Pharmacotherapy · 2025
otherCited 1×
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