Research
Molecular
The effects of rifampicin on obesity are mediated through Sirt6.
Targeting Sirt6 may enhance the effectiveness of rifampicin in obesity treatment.
StrongSupportsmedium confidence
Importantly, deletion of adipose Sirt6 abolishes the effects of rifampicin on HFD-induced weight gain and obesity in mice.
Why this rating
The conclusion is drawn from experimental evidence presented in the abstract.
Source
Rifampicin prevents diet-induced obesity through Sirt6-dependent lipolysis, adipocyte browning and lipogenesis inhibition
Yang Xu et al. · Biomedicine & Pharmacotherapy · 2025
DOI 10.1016/j.biopha.2025.118226
otherCited 1×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
More from this paper
Related findings · Molecular
- QRISK decreased markedly after weight loss from 18.9 ± 2.2% to 11.2 ± 1.6%, p < 0.0001.Strong
- Normalization of 10-year cardiovascular risk and heart age is possible after substantial dietary weight loss and remission of T2DM.Strong
- The Low-Fat Plus diet resulted in a greater reduction in total cholesterol compared to the Low-Fat diet, with changes of -0.46 mmol/L (-17.6 mg/dL) versus -0.24 mmol/L (-9.2 mg/dL) respectively (P = 0.01).Strong
This is one finding among thousands. Every one is graded and traced to its source, so you can see what the evidence actually supports. Browse the research →