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Mice receiving NN501 display a more gradual weight regain and no compensatory hyperphagic response after treatment cessation.
NN501 may help in maintaining weight loss without the rebound effects seen with other treatments.
StrongSupportsmedium confidence
When treatment is discontinued, mice receiving NN501 display a more gradual weight regain and no compensatory hyperphagic response.
Why this rating
Based on the study design from the abstract.
Source
Analog of prolactin-releasing peptide reduces body weight primarily through sustained fatty acid oxidation rather than hypophagia
Claire H. Feetham et al. · Cell Metabolism · 2025
DOI 10.1016/j.cmet.2025.10.021
otherCited 1×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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