Research
Hormonal
Semaglutide significantly reduced the risk of major limb events (LEs) compared with control interventions, with an odds ratio of 0.70 (95% CI 0.60–0.82; P < 0.0001).
Semaglutide may be an effective treatment option for reducing the risk of PAD-related complications in patients with diabetes or obesity.
StrongSupportsmedium confidence
Semaglutide significantly reduced the risk of LEs compared with control interventions (OR 0.70; 95% CI 0.60–0.82; P < 0.0001).
Why this rating
Based on a meta-analysis of 19 randomized controlled trials.
Source
Impact of semaglutide on limb events: a meta-analysis of randomized controlled trials
Arturo Cesaro et al. · European Journal of Preventive Cardiology · 2026
DOI 10.1093/eurjpc/zwag077
Meta-analysisCited 1×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
More from this paper
- The protective effect of semaglutide on limb events was consistent across patient subgroups, including those with diabetes and obesity.Strong
- Meta-regression showed no significant effect modification by age, body mass index, HbA1c, follow-up duration, or sodium-glucose co-transporter 2 inhibitors use.Strong
Related findings · Hormonal
- Initial treatment for type 2 diabetes should be a combination of metformin and either an SGLT-2 inhibitor or a GLP-1 receptor agonist to achieve cardiorenal protection, rather than monotherapy or older agents like sulfonylureas.Strong
- For patients with specific monogenic obesity syndromes (leptin deficiency, POMC/PCSK1/LEPR mutations), targeted pharmacotherapy (recombinant leptin or setmelanotide) is highly effective and should be prioritized, unlike in polygenic obesity.Strong
- Continued weekly administration of 2.4 mg subcutaneous semaglutide prevents weight regain and promotes further weight loss in adults with overweight or obesity, whereas switching to placebo results in significant weight regain.Strong
This is one finding among thousands. Every one is graded and traced to its source, so you can see what the evidence actually supports. Browse the research →