Research
Hormonal
The protective effect of semaglutide on limb events was consistent across patient subgroups, including those with diabetes and obesity.
Semaglutide can be considered for diverse populations at risk of PAD.
StrongSupportsmedium confidence
Benefits were consistent across patient subgroups, in patients with diabetes (OR 0.70; 95% CI: 0.57–0.87; P = 0.001) or obesity (OR 0.71; 95% CI: 0.56–0.89; P = 0.003).
Why this rating
Based on a meta-analysis of 19 randomized controlled trials.
Source
Impact of semaglutide on limb events: a meta-analysis of randomized controlled trials
Arturo Cesaro et al. · European Journal of Preventive Cardiology · 2026
DOI 10.1093/eurjpc/zwag077
Meta-analysisCited 1×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
More from this paper
- Semaglutide significantly reduced the risk of major limb events (LEs) compared with control interventions, with an odds ratio of 0.70 (95% CI 0.60–0.82; P < 0.0001).Strong
- Meta-regression showed no significant effect modification by age, body mass index, HbA1c, follow-up duration, or sodium-glucose co-transporter 2 inhibitors use.Strong
Related findings · Hormonal
- Initial treatment for type 2 diabetes should be a combination of metformin and either an SGLT-2 inhibitor or a GLP-1 receptor agonist to achieve cardiorenal protection, rather than monotherapy or older agents like sulfonylureas.Strong
- For patients with specific monogenic obesity syndromes (leptin deficiency, POMC/PCSK1/LEPR mutations), targeted pharmacotherapy (recombinant leptin or setmelanotide) is highly effective and should be prioritized, unlike in polygenic obesity.Strong
- Continued weekly administration of 2.4 mg subcutaneous semaglutide prevents weight regain and promotes further weight loss in adults with overweight or obesity, whereas switching to placebo results in significant weight regain.Strong
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