Research
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Meta-regression showed no significant effect modification by age, body mass index, HbA1c, follow-up duration, or sodium-glucose co-transporter 2 inhibitors use.
The effectiveness of semaglutide is consistent regardless of these common patient characteristics.
StrongSupportsmedium confidence
Meta-regression showed no significant effect modification by age, body mass index, HbA1c, follow-up duration, or sodium-glucose co-transporter 2 inhibitors use.
Why this rating
Based on a meta-analysis of 19 randomized controlled trials.
Source
Impact of semaglutide on limb events: a meta-analysis of randomized controlled trials
Arturo Cesaro et al. · European Journal of Preventive Cardiology · 2026
DOI 10.1093/eurjpc/zwag077
Meta-analysisCited 1×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
More from this paper
- Semaglutide significantly reduced the risk of major limb events (LEs) compared with control interventions, with an odds ratio of 0.70 (95% CI 0.60–0.82; P < 0.0001).Strong
- The protective effect of semaglutide on limb events was consistent across patient subgroups, including those with diabetes and obesity.Strong
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