Research
Hormonal
Leptin receptor deficiency in db/db mice abolished the weight reduction effect of MPDA@TZP via iWAT local injection compared to that in DIO mice.
Leptin receptor status should be considered when evaluating treatment efficacy for obesity.
StrongSupportsmedium confidence
Leptin receptor deficiency in db/db mice abolished the weight reduction effect of MPDA@TZP via iWAT local injection compared to that in DIO mice.
Why this rating
The claim is based on direct experimental observations in the study.
Source
Tirzepatide retention in iWAT with mesoporous polydopamine encapsulation enhances weight loss through leptin receptor signaling
Lin Mi et al. · Journal of Advanced Research · 2025
DOI 10.1016/j.jare.2025.09.009
otherCited 1×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
More from this paper
- MPDA@TZP increased the retention time of TZP in the iWAT of mice and had a more dramatic effect on weight loss and improvement in plasma lipid profiles compared to TZP alone in DIO mice.Strong
- iWAT injection of MPDA@TZP improved leptin resistance, beiging, lipid metabolism, mitochondrial activity, and branched-chain amino acid (BCAA) catabolism in iWAT.Strong
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