Research
Molecular
iWAT injection of MPDA@TZP improved leptin resistance, beiging, lipid metabolism, mitochondrial activity, and branched-chain amino acid (BCAA) catabolism in iWAT.
Understanding these metabolic improvements can guide targeted therapies for obesity.
StrongSupportsmedium confidence
Transcriptomic analysis indicated that iWAT injection of MPDA@TZP improved leptin resistance, beiging, lipid metabolism, mitochondrial activity and branched-chain amino acid (BCAA) catabolism in iWAT.
Why this rating
Based on the detailed transcriptomic analysis conducted in the study.
Source
Tirzepatide retention in iWAT with mesoporous polydopamine encapsulation enhances weight loss through leptin receptor signaling
Lin Mi et al. · Journal of Advanced Research · 2025
DOI 10.1016/j.jare.2025.09.009
otherCited 1×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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- MPDA@TZP increased the retention time of TZP in the iWAT of mice and had a more dramatic effect on weight loss and improvement in plasma lipid profiles compared to TZP alone in DIO mice.Strong
- Leptin receptor deficiency in db/db mice abolished the weight reduction effect of MPDA@TZP via iWAT local injection compared to that in DIO mice.Strong
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