Research
Energy balance
The optimal SPAN combination of 8.0-9.4 h/day sleep, 42-104 min/day MVPA, and a DQS of 32.5-50.0 was associated with a 57% lower risk of major adverse cardiovascular events (MACE) (HR: 0.43; 95% CI: 0.30, 0.62).
Practitioners should encourage optimal sleep, physical activity, and nutrition combinations to reduce cardiovascular event risk.
StrongSupportsmedium confidence
Compared with the lowest tertile for all SPAN behaviours, the optimal SPAN combination of 8.0-9.4 h/day sleep, 42-104 min/day MVPA, and a DQS of 32.5-50.0 was associated with a 57% lower risk of MACE (HR: 0.43; 95% CI: 0.30, 0.62).
Why this rating
Based on a large prospective cohort study.
Source
Combined variations in sleep, physical activity, and nutrition and the risk of major adverse cardiovascular events
Nicholas A. Koemel et al. · European Journal of Preventive Cardiology · 2026
DOI 10.1093/eurjpc/zwag141
cohort · n=53242Cited 1×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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