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A median SPAN score (52.8) was associated with a 41% lower risk of MACE (HR: 0.59; 95% CI: 0.49, 0.70).
Practitioners should aim for a balanced SPAN score to lower cardiovascular event risk.
StrongSupportsmedium confidence
A median SPAN score (52.8) was associated with a 41% lower risk of MACE (HR: 0.59; 95% CI: 0.49, 0.70).
Why this rating
Based on a large prospective cohort study.
Source
Combined variations in sleep, physical activity, and nutrition and the risk of major adverse cardiovascular events
Nicholas A. Koemel et al. · European Journal of Preventive Cardiology · 2026
DOI 10.1093/eurjpc/zwag141
cohort · n=53242Cited 1×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
More from this paper
- The optimal SPAN combination of 8.0-9.4 h/day sleep, 42-104 min/day MVPA, and a DQS of 32.5-50.0 was associated with a 57% lower risk of major adverse cardiovascular events (MACE) (HR: 0.43; 95% CI: 0.30, 0.62).Strong
- A minimum combined variation of an additional 11 min/day of sleep, 4.5 min/day MVPA, and 3 DQS points was associated with 10% lower MACE risk (HR: 0.90; 0.88, 0.94).Strong
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