Research
Molecular
One standard deviation higher polygenic score (PS) related to smaller one-year change in waist circumference adjusted for body mass index (WCadjBMI) in the lifestyle intervention arms at year 1, predicting poorer response among White participants overall.
Practitioners should consider genetic factors when assessing weight loss responses to lifestyle interventions.
StrongSupportsmedium confidence
One standard deviation higher PS related to smaller one-year change in WCadjBMI in the lifestyle intervention arms at year 1.
Why this rating
Based on the design of the lifestyle intervention trials mentioned.
Source
Genetic Predictors of Change in Waist Circumference and Waist-To-Hip Ratio with Lifestyle Intervention: the Trans-NIH consortium for Genetics of Weight Loss Response to Lifestyle Intervention
Jeanne M. McCaffery et al. · 2022
other
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