Research
Molecular
At average weight loss, the effect of a higher PS amounted to a change of 0.20-0.28 cm per standard deviation in WCadjBMI.
The small effect size suggests that genetic factors may have limited practical implications for weight loss interventions.
StrongSupportsmedium confidence
At average weight loss, this amounted to 0.20-0.28 cm per standard deviation.
Why this rating
Based on the design of the lifestyle intervention trials mentioned.
Source
Genetic Predictors of Change in Waist Circumference and Waist-To-Hip Ratio with Lifestyle Intervention: the Trans-NIH consortium for Genetics of Weight Loss Response to Lifestyle Intervention
Jeanne M. McCaffery et al. · 2022
DOI 10.2337/figshare.17890715.v1
other
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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- One standard deviation higher polygenic score (PS) related to smaller one-year change in waist circumference adjusted for body mass index (WCadjBMI) in the lifestyle intervention arms at year 1, predicting poorer response among White participants overall.Strong
- No significant findings emerged in White women, African American men, or for the 8-10 week outcomes or for waist-to-hip ratio adjusted for body mass index (WHRadjBMI).Strong
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