Research
Molecular
A stronger decline in sACE2 during the diet intervention was independently associated with improvements in metabolic health markers.
Improvements in metabolic health may be linked to changes in sACE2 levels during weight loss.
StrongSupportsmedium confidence
A stronger decline in sACE2 during the diet intervention was independently associated with female sex, lower HOMA-IR and LDL cholesterol at baseline, and a stronger decline in HOMA-IR, triglycerides, HDL-cholesterol and fat mass.
Why this rating
Based on the analysis of biochemical markers in a large cohort.
Source
The association of soluble ACE2 change with metabolic health, body composition and proteome dynamics during a weight loss diet intervention: implications for the COVID-19 pandemic
Nicholas Cauwenberghs et al. · European Heart Journal · 2021
cohort · n=457
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