Research
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52.9% of Semaglutide users reached the 2.4 mg dose compared to 77.6% of Tirzepatide users reaching 15 mg.
Practitioners should note the higher success rate of Tirzepatide in reaching the maintenance dose.
StrongSupportsmedium confidence
Among 739 medication courses, 52.9% of Semaglutide users reached the 2.4 mg dose versus 77.6% of tirzepatide users reaching 15 mg (p < 0.001).
Why this rating
Based on the retrospective observational study design with a substantial sample size.
Source
Evaluating Dose Titration in Semaglutide and Tirzepatide for Weight Loss: A Retrospective Academic Call Center Study
Goar Alvarez et al. · Obesities · 2025
DOI 10.3390/obesities5040090
cohort · n=739
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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