Research
Energy balance
Median time to maintenance was significantly shorter for Tirzepatide (32 days) than Semaglutide (143 days).
Practitioners may prefer Tirzepatide for quicker dose optimization.
StrongSupportsmedium confidence
Median time to maintenance was significantly shorter for tirzepatide (32 days) than Semaglutide (143 days) (p < 0.001).
Why this rating
Based on the retrospective observational study design with a substantial sample size.
Source
Evaluating Dose Titration in Semaglutide and Tirzepatide for Weight Loss: A Retrospective Academic Call Center Study
Goar Alvarez et al. · Obesities · 2025
DOI 10.3390/obesities5040090
cohort · n=739
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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