Research
Metabolic adaptation
GC ablation in mice fed a high fat diet protects against obesity and type 2 diabetes.
This suggests that targeting GC could be beneficial in preventing obesity in high-fat diet scenarios.
StrongSupportsmedium confidence
Among mice fed a high fat diet, Gc ablation confers protection against the development of obesity and type 2 diabetes.
Why this rating
The claim is based on experimental evidence from studies of mice.
Source
On the potential of group-specific component (GC) inhibition for treating metabolic disease
Richard Gill et al. · Metabolism and Target Organ Damage · 2026
DOI 10.20517/mtod.2025.195
review
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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