Research
Energy balance
Inhibiting GC does not lead to reductions in food intake or lean mass.
This indicates that GC inhibition could be a safer alternative to current treatments that suppress appetite.
StrongSupportsmedium confidence
Notably, these benefits came without reductions in food intake or lean mass.
Why this rating
The claim is based on observations from studies of GC-null mice.
Source
On the potential of group-specific component (GC) inhibition for treating metabolic disease
Richard Gill et al. · Metabolism and Target Organ Damage · 2026
DOI 10.20517/mtod.2025.195
review
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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