Research
Hormonal
Early discontinuation of GLP-1RA therapy is associated with increased risks of coronary artery disease and heart failure.
Clinicians should be aware of the cardiovascular risks when patients discontinue GLP-1RA therapy early.
StrongSupportsmedium confidence
Early discontinuation (< 1 year) is associated with increased risks of coronary artery disease and heart failure compared with continued therapy.
Why this rating
Based on evidence from randomized withdrawal trials.
Source
Clinical Management of Weight Regain and Cardiometabolic Consequences After Discontinuation of <scp>GLP</scp> ‐1 Receptor Agonists
E Abu Shah et al. · Diabetes Obesity and Metabolism · 2026
Meta-analysis
Read the paper This is one finding among thousands. Every one is graded and traced to its source, so you can see what the evidence actually supports. Browse the research →