Research
Metabolic adaptation
Metabolic parameters such as glycaemic, blood pressure, and lipid levels return to baseline within approximately 12 months after discontinuation.
Healthcare providers should monitor metabolic parameters closely after discontinuation of GLP-1RA therapy.
StrongSupportsmedium confidence
Modelling studies suggest that glycaemic, blood pressure, and lipid parameters return to baseline within approximately 12 months.
Why this rating
Based on modelling studies referenced in the abstract.
Source
Clinical Management of Weight Regain and Cardiometabolic Consequences After Discontinuation of <scp>GLP</scp> ‐1 Receptor Agonists
E Abu Shah et al. · Diabetes Obesity and Metabolism · 2026
Meta-analysis
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