Research
Metabolic adaptation
Discontinuation of GLP-1 receptor agonists is associated with substantial weight regain of 60%-90% within one year.
Clinicians should anticipate significant weight regain in patients discontinuing GLP-1RA therapy.
StrongSupportsmedium confidence
Discontinuation is associated with substantial weight regain (60%-90% within one year) and parallel reversal of cardiometabolic benefits.
Why this rating
Based on evidence from randomized withdrawal trials and large observational cohorts.
Source
Clinical Management of Weight Regain and Cardiometabolic Consequences After Discontinuation of <scp>GLP</scp> ‐1 Receptor Agonists
E Abu Shah et al. · Diabetes Obesity and Metabolism · 2026
DOI 10.1111/dom.70713
Meta-analysis
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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